The purpose of this paper is to present a differential equation with delay from biological excitable medium. Existence, uniqueness and data dependence (monotony, continuity, differentiability with respect to parameter) results for the solution of the Cauchy problem of biological excitable medium are obtained using weakly Picard operator theory.
Authors
Diana Otrocol Tiberiu Popoviciu Institute of Numerical Analysis, Romanian Academy
[1] J. K. Hale, Introduction to functional differential equations, Springer-Verlag, 1993.
[2] B. N. Hidirov, Regulation mechanism of living system, J. Scientiae Mathematicae Japonicae 64(2006), No.2, 497-504.
[3] M. B. Hidirova, Dynamics of biological excitable medium, J. Scientiae Mathematicae Japonicae 64(2006), No.2, 755-763.
[4] V. Mure¸san, Functional-Integral Equations, Mediamira, Cluj-Napoca, 2003.
[5] D. Otrocol, Data dependence for the solution of a Lotka-Volterra system with two delays, Mathematica 48(2006), No.71, 61-68.
[6] D. Otrocol, Lotka-Volterra system with two delays via weakly Picard operators, Nonlinear Analysis Forum 10(2005), No.2, 193-199.
[7] I. A. Rus, Picard operators and applications, J. Scientiae Mathematicae Japonicae 58(2003), No.1, 191-219.
[8] I. A. Rus, Generalized Contractions and Applications, Cluj University Press, 2001.
[9] I. A. Rus, Weakly Picard operators and applications, Seminar of Fixed Point Theory, ClujNapoca, 2(2001), 41-58.
[10] M. Saidalieva, Modelling of regulation mechanism of cellular communities, J. Scientiae Mathematicae Japonicae 8(2003), 463-469.
[11] M. A. S¸erban, Fiber φ-contractions, Studia Univ. ”Babe¸s-Bolyai”, Mathematica 44(1999), No.3 , 99-108.
Paper (preprint) in HTML form
A DIFFERENTIAL EQUATION WITH DELAY FROM BIOLOGY
DIANA OTROCOL
Abstract
The purpose of this paper is to present a differential equation with delay from biological excitable medium. Existence, uniqueness and data dependence (monotony, continuity, differentiability with respect to parameter) results for the solution of the Cauchy problem of biological excitable medium are obtained using weakly Picard operator theory.
AMS Mathematics Subject Classification : 47H10, 47N20.
Key words and phrases : excitable medium, differential-delay equations, weakly Picard operator.
1. Introduction
In recent years the theory of excitable medium has rapidly developed and its results have been applied in various areas: chemistry, biology, ecology, electric engineering, populations dynamics, cardiology, neurology. At present, different approaches for the mathematical description of biological excitable medium by means of partial-differential equation, functional-differential, functional and discrete equations are applied. The papers [2], [3], [10] has offered the opportunity for understanding the normal regulation of living systems as well as its anomalies.
The activity of the -th element of the excitable medium can be described by the following equation:
(1)
where is the activity of the -th element; is the functional parameter of the -th element; is the feedback function; is the decay constant, .
The aim of this paper is to study the following problem
(2)
, with initial conditions
(3)
where
;
there exists , such as:
for all .
By a solution of the problem (2)-(3) we understand the function with which satisfies (2)-(3).
The problem (2)-(3) is equivalent with the following fixed point system:
where .
On the other hand, the system (2) is equivalent with
where .
In this paper we apply the weakly Picard operators technique to study the systems (4) and (5).
2. Weakly Picard operators
I.A. Rus introduced the Picard operators class and the weakly Picard operators class (WPO) for the operators defined on a metric space and he gave basic notations, definitions and results in this field in many papers [7]-[9]. Some problems concerning this techniques were study in [4], [11], [5], [6].
Let ( ) be a metric space and an operator. We shall use the following notations:
- the fixed point set of ;
- the family of the nonempty invariant subset of ;
- the set of the parts of ;
-the Pompeiu-Housdorff functional on .
Definition 1. ([7], [9]) Let ( ) be a metric space. An operator is a Picard operator if there exists such that:
(i) ;
(ii) the sequence converges to for all .
Remark 1. ([7], [9]) Accordingly to the definition, the contraction principle insures that, if is an -contraction on the complete metric space , then it is a Picard operator.
Theorem 1. ([7], [9]) (Data dependence theorem). Let ( ) be a complete metric space and two operators. We suppose that
(i) the operator is a -contraction;
(ii) ;
(iii) there exists such that
Then, if and , we have
Definition 2. ([7], [9]) Let ( ) be a metric space. An operator is a weakly Picard operator (WPO) if the sequence converges for all , and its limit (which may depend on ) is a fixed point of .
Theorem 2. ([7], [9]) Let be a metric space and an operator. The operator is weakly Picard operator if and only if there exists a partition of ,
where is the indices set of partition, such that:
(a) ;
(b) is a Picard operator for all .
Definition 3. ([7], [9]) If is weakly Picard operator then we consider the operator defined by
It is clear that .
Definition 4. ([7], [9]) Let be a weakly Picard operator and . The operator is -weakly Picard operator if
Example 1. ([7], [9]) Let be a complete metric space and a continuous operator. We suppose that there exists such that
Then is -weakly Picard operator with .
Theorem 3. ([7], [9]) Let ( ) be a metric space and . Suppose that
(i) the operator is -weakly Picard operator, ;
(ii) there exists such that
Then .
Theorem 4. ([7], [9]) (Fibre contraction principle). Let ( ) and ( ) be two metric spaces and a triangular operator. We suppose that
(i) is a complete metric space;
(ii) the operator is Picard operator;
(iii) there exists such that is a -contraction, for all ;
(iv) if , then is continuous in .
Then the operator is Picard operator.
3. Cauchy problem
We consider the fixed point system (4).
Let given by the relation
where
We consider the Banach space with the Chebyshev norm . Let .
We have the following result
Theorem 5. We suppose that
(i) the conditions are satisfied;
(ii) .
Then the Cauchy problem (2)-(3) has in a unique solution. Moreover, the operator is c-Picard with
Proof. For , we have
.
For , we have
Then
So is -Picard operator with , where .
In what follows, we consider the following operator
given by
where
Theorem 6. In the condition of Theorem 5, is WPO.
Proof. The operator is a continuous operator but it is not a contraction. Let take the following notation:
Then we can write
(6)
We have that and is a Picard operator, because it is the operator which appears in the proof of the Theorem 5. By applying the Theorem 2, we obtain that is WPO.
4. Increasing solutions of the system (2)
4.1. Inequalities of Caplygin type
Theorem 7. We suppose that
(a) the conditions of the Theorem 5 are satisfied;
(b) implies that
Let be a solution of the system (2) and ( ) a solution of the inequality system
Then implies that .
Proof. In the terms of the operator , we have
However, from the condition (b), we have that is increasing,
Thus .
Here, we use the notation .
4.2. Comparison theorem
In what follows we want to study the monotony of the solution of the problem (2)-(3), with respect to and . We shall use the result below:
Lemma 1. (Abstract comparison Lemma). Let be an ordered metric space and be such that:
(i) ;
(ii) the operators are WPO;
(iii) the operator is increasing
Then .
In this case we can establish the theorem.
Theorem 8. Let .
We suppose that
(a) is increasing, ;
(b) .
Let be a solution of the equation
where .
If , then .
Proof. From Theorem 5, the operators are weakly Picard operators.
Taking into consideration the condition (a), the operator is increasing.
From (b) we have that .
We note that . Now using the abstract comparison lemma, the proof is complete.
5. Data dependence: continuity
Consider the Cauchy problem (2)-(3) and suppose the conditions of the Theorem 5 are satisfied. Denote by , the solution of this problem. We can state the following result:
Theorem 9. Let be as in the Theorem 5. Furthermore, we suppose that there exists such that
(i) ;
(ii) .
Then
where .
Proof. Consider the operators . From Theorem 5 these operators are contractions.
Additionally
.
Now the proof follows from the Theorem 1, with and where .
From the Theorem above we have:
Theorem 10. Let and be as in the Theorem 5, . Let be the solution set of system (2) corresponding to and . Suppose that there exists such that
(7)
for all .
Then
where and denotes the Pompeiu-Housdorff functional with respect to on .
Proof. In condition of the Theorem 5, the operators and are -WPO and -weakly Picard operators.
Let
It is clear that . So, from Theorem 2 and Theorem 5 we have
for all .
Now, choosing
we get that and are -weakly Picard operators and -weakly Picard operators with and . From (7) we obtain that
. Applying Theorem 3 we have that
where and is the Pompeiu-Housdorff functional with respect to on .
6. Data dependence: differentiability
Consider the following differential system with parameter
(8)
(9)
Suppose that we have satisfied the following conditions:
a compact interval;
;
there exists such that
( ) .
Then, from Theorem 5, we have that the problem (2)-(3) has a unique solution, .
We prove that .
For this we consider the system
(10)
.
Theorem 11. Consider the problem (10)-(9), and suppose the conditions ( ) hold. Then,
(i) (10)-(9) has a unique solution , in
(ii) .
Proof. The problem (10)-(9) is equivalent with the following functional-integral equation
Now let take the operator
given by
where
Let .
It is clear, from the proof of the Theorem 5, that in the condition , the operator is Picard operator.
Let be the unique fixed point of .
Supposing that there exists , from (11), we have that
for all .
This relation suggest us to consider the following operator
where for and
for .
In this way we have the triangular operator
where is Picard operator and is -contraction with .
From Theorem 4 we have that the operator is Picard operator, i.e. the sequences
, converges uniformly, with respect to , to , for all .
If we take
then
By induction we prove that
So
From a Weierstrass argument we have that there exists and
References
1.
J. K. Hale, Introduction to functional differential equations, Springer-Verlag, 1993.
2.
B. N. Hidirov, Regulation mechanism of living system, J. Scientiae Mathematicae Japonicae 64(2006), No.2, 497-504.
3.
M. B. Hidirova, Dynamics of biological excitable medium, J. Scientiae Mathematicae Japonicae 64(2006), No.2, 755-763.
4.
V. Mureşan, Functional-Integral Equations, Mediamira, Cluj-Napoca, 2003.
5.
D. Otrocol, Data dependence for the solution of a Lotka-Volterra system with two delays, Mathematica 48(2006), No.71, 61-68.
6.
D. Otrocol, Lotka-Volterra system with two delays via weakly Picard operators, Nonlinear Analysis Forum 10(2005), No.2, 193-199.
7.
I. A. Rus, Picard operators and applications, J. Scientiae Mathematicae Japonicae 58(2003), No.1, 191-219.
8.
I. A. Rus, Generalized Contractions and Applications, Cluj University Press, 2001.
9.
I. A. Rus, Weakly Picard operators and applications, Seminar of Fixed Point Theory, ClujNapoca, 2(2001), 41-58.
10.
M. Saidalieva, Modelling of regulation mechanism of cellular communities, J. Scientiae Mathematicae Japonicae 8(2003), 463-469.
11.
M. A. Şerban, Fiber -contractions, Studia Univ. "Babeş-Bolyai", Mathematica 44(1999), No. 3 , 99-108.
Diana Otrocol received her Ph.D at Babeş-Bolyai University under the direction of Petru Blaga. Now she is a research assistant at the Tiberiu Popoviciu Institute of Numerical Analysis. Her research interests focus on the fixed point theory and numerical analysis.
Tiberiu Popoviciu Institute of Numerical Analysis, Cluj-Napoca, Romania
e-mail: dotrocol@ictp.acad.ro
A Differential equation with delay from biology
Diana Otrocol
Abstract.
The purpose of this paper is to present a differential equation with
delay from biological excitable medium. Existence, uniqueness and
data dependence (monotony, continuity, differentiability with
respect to parameter) results for the solution of the Cauchy problem
of biological excitable medium are obtained using weakly Picard
operator theory.
Key words and phrases : excitable medium,
differential-delay equations, weakly Picard operator.
This work has been supported by MEdC-ANCS under grant 2-CEx06-11-96/19.09.2006.
1. Introduction
In recent years the theory of excitable medium has rapidly developed
and its results have been applied in various areas: chemistry,
biology, ecology, electric engineering, populations dynamics,
cardiology, neurology. At present, different approaches for the
mathematical description of biological excitable medium by means of
partial-differential equation, functional-differential, functional
and discrete equations are applied. The papers [3],
[4], [11] has offered the opportunity for
understanding the normal regulation of living systems as well as its
anomalies.
The activity of the -th element of the excitable medium can be
described by
the following equation:
(1)
where is the activity of the -th element; is
the functional parameter of the -th element; is
the feedback function; is the decay constant,
The aim of this paper is to study the following problem
(2)
with initial conditions
(3)
where
(H1)
(H2)
(H3)
(H4)
there exists such as:
for all
By a solution of the problem (2)–(3) we
understand the function
with
which satisfies
(2)–(3).
The problem (2)–(3) is equivalent with the
following
fixed point system:
(4)
where
On the other hand, the system (2) is equivalent with
(5)
where
In this paper we apply the weakly Picard operators technique to
study the systems (4) and (5).
2. Weakly Picard operators
I.A. Rus introduced the Picard operators class (PO) and the weakly
Picard operators class (WPO) for the operators defined on a metric
space and he gave basic notations, definitions and results in this
field in many papers [8]–[10]. Some problems
concerning this techniques were study in [5],
[12], [6], [7].
Let be a metric space and an operator. We
shall use the following notations:
- the fixed point set of ;
- the family
of the nonempty invariant subset of ;
;
- the set of the parts of
-the Pompeiu–Housdorff functional on .
Definition 1.
([8], [10])
Let be a metric space. An operator
is a Picard operator (PO) if there exists
such that:
(i)
(ii)
the sequence
converges to for all .
Remark 1.
([8], [10])
Accordingly to the definition, the contraction
principle insures that, if is an
-contraction on the complete metric space , then it is a Picard
operator.
Theorem 1.
([8], [10])
(Data dependence theorem). Let be a
complete metric space and two operators. We
suppose that
(i)
the operator is a -contraction;
(ii)
(iii)
there exists such that
Then, if and we have
Definition 2.
([8], [10])
Let be a metric space. An operator
is a weakly Picard operator (WPO) if the
sequence converges for all , and its
limit (which may depend on ) is a fixed point of .
Theorem 2.
([8], [10])
Let be a metric space and
an operator. The operator is weakly Picard operator if and only
if there
exists a partition of ,
where is the indices set of partition, such that:
(a)
;
(b)
is a Picard operator for all .
Definition 3.
([8], [10])
If is weakly Picard operator then we consider
the
operator defined by
It is clear that
Definition 4.
([8], [10])
Let be a weakly Picard operator and The
operator
is -weakly Picard operator if
Example 1.
([8], [10])
Let be a complete metric space and
a continuous operator. We suppose that there
exists
such that
Then is -weakly Picard operator with
Theorem 3.
([8], [10])
Let be a metric space and
Suppose that
(i)
the operator is -weakly Picard operator,
(ii)
there exists such that
Then
Theorem 4.
([8], [10])
(Fibre contraction principle). Let
and be two metric spaces and a triangular operator. We suppose that
(i)
is a complete metric space;
(ii)
the operator is Picard operator;
(iii)
there exists such that
is a -contraction, for all ;
The operator is a continuous operator but it is not a
contraction. Let
take the following notation:
Then we can write
(6)
We have that and
is a
Picard operator, because it is the operator which appears in the
proof of the Theorem 5. By applying the Theorem
2, we obtain that is WPO.
∎
Let be a solution of the system
(2) and
a solution of the inequality system
Then implies that
Proof.
In the terms of the operator , we have
However, from the condition (b), we have that is increasing,
Thus
Here, we use the notation
∎
4.2. Comparison theorem
In what follows we want to study the monotony of the solution of the
problem (2)–(3), with respect to
and We shall use the
result below:
Lemma 1.
(Abstract comparison Lemma). Let
be an ordered metric space and
be such that:
(i)
(ii)
the operators are WPO;
(iii)
the operator is increasing
Then
In this case we can establish the theorem.
Theorem 8.
Let
We suppose that
(a)
is increasing, ;
(b)
Let be a solution of the equation
where
If then
Proof.
From Theorem 5, the operators are
weakly Picard operators.
Taking into consideration the condition (a), the operator
is increasing.
From (b) we have that .
We note that . Now using the
abstract comparison lemma, the proof is complete.
∎
5. Data dependence: continuity
Consider the Cauchy problem (2)–(3) and
suppose the conditions of the Theorem 5 are satisfied.
Denote by
the solution of this problem. We can state
the following result:
Theorem 9.
Let be as in the Theorem 5. Furthermore, we suppose
that there exists such
that
(i)
(ii)
Then
where
Proof.
Consider the operators
From Theorem
5 these operators are contractions.
Additionally
Now the proof follows from the Theorem 1, with
and where
∎
From the Theorem above we have:
Theorem 10.
Let and be as in the Theorem
5, . Let
be the solution set of system
(2) corresponding to and
. Suppose that there exists such that
(7)
for all
Then
where and denotes the Pompeiu-Housdorff functional
with respect to on
Proof.
In condition of the Theorem 5, the operators
and are -WPO
and -weakly Picard operators.
Let
It is clear that So, from Theorem
2 and
Theorem 5 we have
for all
Now, choosing
we get that and are -weakly
Picard
operators and -weakly Picard operators with and . From (7) we
obtain
that
[6]D. Otrocol, Data dependence for the solution of a
Lotka-Volterra system with two delays, Mathematica 48(2006),
No.71, 61-68.
[7]D. Otrocol, Lotka-Volterra system with two delays
via weakly Picard operators, Nonlinear Analysis Forum 10(2005), No.2, 193-199.
[8]I. A. Rus, Picard operators and applications, J. Scientiae Mathematicae Japonicae 58(2003), No.1,
191-219.
[9]I. A. Rus, Generalized Contractions and Applications,
Cluj University Press, 2001.
[10]I. A. Rus, Weakly Picard operators and applications,
Seminar of Fixed Point Theory, Cluj-Napoca, 2(2001), 41-58.
[11]M. Saidalieva, Modelling of regulation mechanism
of cellular communities, J. Scientiae Mathematicae Japonicae 8(2003), 463-469.
[12]M. A. Şerban, Fiber -contractions, Studia Univ. ”Babeş-Bolyai”, Mathematica 44(1999), No.3 , 99-108.
Diana Otrocol received her Ph.D at
Babeş-Bolyai University under the direction of Petru Blaga. Now she is a research assistant at the Tiberiu Popoviciu Institute of Numerical Analysis. Her
research interests focus on the fixed point theory and numerical
analysis.
Tiberiu Popoviciu Institute of Numerical Analysis, Cluj-Napoca,
Romania e-mail: dotrocol@@ictp.acad.ro